The following organizations promote local business interests with support of members from their communities.

• Asian Business Association Small Business Development Center (ABASD SBDC)
• Somali Bantu Association of America
• Central San Diego Black Chamber of Commerce
• Mira Mesa Chamber of Commerce
• Old Town Chamber of Commerce
• Otay Mesa Chamber of Commerce
• Peninsula Chamber of Commerce
• North San Diego Business Chamber
• San Diego Regional Chamber of Commerce
• San Ysidro Chamber of Commerce
• San Diego County Hispanic Chamber of Commerce
• East County Economic Development Council
• San Diego North Economic Development Council
• San Diego Regional Economic Development Corp.
• South County Economic Development Council
• Barrio Logan Association
• Bayside Community Center
• Tijuana Economic Development Council